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There is good evidence that HPV causes many anal squamous cell carcinomas. Warts containing HPV-6 or HPV-11 are much less likely to become cancerous than those containing HPV-16.

But the role of this virus in causing anal adenocarcinomas is less certain. The subtype known as HPV-16 is often found in squamous cell carcinoma and is also found in some anal warts. HPV makes proteins (E6 and E7) that can shut down 2 important tumor suppressor proteins in normal cells.

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